Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• diagnostic technologies. With further refinement and advancements, GNC-based photothermal assays could revolutionize the field of point-of-care diagnostics and reliable disease detection. Recent studies have proven the applicability of multimodal LFAs for accurate and quantitative diagnosis. Yang et al

Fabrication and testing of polymer microneedles for transdermal drug delivery

• Vahid Ebrahiminejad,
• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2022, 13, 629–640, doi:10.3762/bjnano.13.55

• considerable potential for medical applications such as transdermal drug delivery, point-of-care diagnostics, and vaccination. These miniature microdevices should successfully pierce the skin tissues while having enough stiffness to withstand the forces imposed by penetration. Developing low-cost and simple

• setting. Keywords: hot embossing; microneedles; penetration efficiency; thermoplastic polymers; two-photon polymerization; Introduction During the past two decades, MN devices have become a promising tool for transdermal drug delivery, vaccination, and point-of-care diagnostics [1][2]. MNs are a

• arrays have the potential for collecting interstitial fluid more safely than using glass [40] or silicon MNs. Conclusion MN arrays have considerable potential for cost-effective, rapid, and non-invasive therapeutic drug delivery, vaccination, and point-of-care diagnostics, with potential for self

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• expand the scope for delivery of vaccines and therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics – so-called theranostics. Unskilled and painless applications of microneedle patches for blood collection or drug delivery are two of the advantages of microneedle

• microneedle systems applications, designs, material selection, and manufacturing methods. Keywords: drug delivery; microelectromechanical systems (MEMS); microfabrication; microneedles; point-of-care diagnostics; Introduction The concept of microneedle structures to penetrate painlessly the outermost layer

• channelling of the drug load to the active area [42]. It is likely that some increase in drug concentrations will be necessary, while applying multiple patches over time would mimic catheter infusions. Point-of-care diagnostics In addition to drug delivery, microneedles may be used for drawing blood or

Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection

• Dinusha N. Udukala,
• Hongwang Wang,
• Sebastian O. Wendel,
• Aruni P. Malalasekera,
• Thilani N. Samarakoon,
• Asanka S. Yapa,
• Gayani Abayaweera,
• Matthew T. Basel,
• Pamela Maynez,
• Raquel Ortega,
• Yubisela Toledo,
• Leonie Bossmann,
• Colette Robinson,
• Katharine E. Janik,
• Olga B. Koper,
• Ping Li,
• Massoud Motamedi,
• Daniel A. Higgins,
• Gary Gadbury,
• Gaohong Zhu,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2016, 7, 364–373, doi:10.3762/bjnano.7.33

• reporter molecules are released in rodent models once the nanoworms have reached the cancer site and then excreted in urine. The quantitative detection of the reporter molecules’ concentrations has been achieved by paper chromatography [29]. Although this was a major step forward in developing point-of

• -care diagnostics, it is still more than minimally invasive, because the nanoworms have to be given intravenously. An ideal “liquid biopsy” [30] will require only the drawing of a simple blood sample to detect cancer, without introducing a reagent to the patient’s body first. In this report, we would

Mismatch detection in DNA monolayers by atomic force microscopy and electrochemical impedance spectroscopy

• Maryse D. Nkoua Ngavouka,
• Pietro Capaldo,
• Elena Ambrosetti,
• Giacinto Scoles,
• Loredana Casalis and
• Pietro Parisse

Beilstein J. Nanotechnol. 2016, 7, 220–227, doi:10.3762/bjnano.7.20

• . Due to the relatively simple geometry, the device could be easily further miniaturized and integrated in multiplexed arrays through microfluidic systems, allowing for point-of-care diagnostics. Our results demonstrated that nano-mechanical and EIS strategies are state of the art for the detection of

• mismatched sequences. From the analysis of hybridization kinetics we distinguished the presence of single or multiple mismatches and their relative position. Both nanoarrays and EIS devices hold the premises for parallelization, multiplexing and low-volume analysis, making them amenable for point-of-care

• diagnostics of SNPs. Moreover a comparative analysis between the two techniques allows for a deep understanding of hybridization processes in the presence of single and multiple mismatches. Experimental Fabrication and measurement processes of AFM-based assays Gold-coated substrates were immersed in 300 μM of

Tunable light filtering by a Bragg mirror/heavily doped semiconducting nanocrystal composite

• Ilka Kriegel and
• Francesco Scotognella

Beilstein J. Nanotechnol. 2015, 6, 193–200, doi:10.3762/bjnano.6.18

• very interesting for point-of-care diagnostics [1][2]. Very interesting strategies to fabricate colour filters, without auto-fluorescence, are proposed in the literature [3]. However, in many applications, such as in microfluidic devices, where the detection of more than one analyte is often necessary